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[11] H5N1 pandemic vaccines and the technologies to rapidly

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iphone 7 plus case H5N1 vaccines for chickens exist and are sometimes used, although there are many difficulties that make it especially difficult to decide whether vaccination will do more harm than good. H5N1 pre pandemic vaccines exist in quantities sufficient to inoculate a few million people[6] and might be useful for priming to « boost the immune response to a different H5N1 vaccine tailor made years later to thwart an emerging pandemic ».[7] Japan has inoculated 6,000 health care workers with a pre pandemic vaccine, and is planning how to proceed with widespread vaccinations, particularly workers who would provide utilities during an outbreak.[8][9][10] Switzerland is also considering preemptive vaccination to protect the general public.[11] H5N1 pandemic vaccines and the technologies to rapidly create them are in the H5N1 clinical trials stage but cannot be verified as useful until after a pandemic strain emerges. Efforts to identify the changes that might result in a human communicable strain have resulted in laboratory generated H5N1 with substantially greater affinity for human cellular receptors after a change of just two of the H5 surface proteins.[12] Significantly, mouse antibodies were 10 times less potent against the mutants than against the pre mutated viruses.[12]A strain of H5N1 killed chickens in 1959 in Scotland and turkeys in 1991 in England.[13] This strain was « highly pathogenic » (deadly to birds) but caused neither illness nor death in humans.[14] « The precursor of the H5N1 influenza virus that spread to humans in 1997 was first detected in Guangdong, China, in 1996, when it caused a moderate number of deaths in geese and attracted very little attention. » [15] In 1997, in Hong Kong, 18 humans were infected and 6 died in the first known case of H5N1 infecting humans.[16] H5N1 had evolved from a zero mortality rate to a 33% mortality rate iphone 7 plus case.

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